LYLAB

The Ly Laboratory studies how errors in mitotic cell division reshape somatic genomes and drive cancer evolution. We leverage interdisciplinary approaches spanning cell biology and genetics to address three fundamental questions:

 

1. How do mitotic errors generate complex genomic changes within an individual cell?

2. How can genome instability propagate between neighboring cells?

3. How do chromosome alterations initiate tumors and shape their evolution?

 

A central theme across these questions is the unique biology of micronuclei – abnormal compartments that form when chromosomes improperly segregate during mitosis and become isolated outside of the nucleus. Micronuclei can generate complex genome rearrangements through the catastrophic fragmentation of individual chromosomes (chromothripsis) or become propagated to neighboring cells through intercellular DNA transfer. The genomic changes emerging from these distinct processes can then be shaped by selection during tumorigenesis. By following these distinct outcomes, we seek to understand how a single cell division error generates genetic diversity and changes the evolutionary potential of cell populations.

 

We are committed to fostering a supportive and collaborative laboratory environment that provides exceptional training and career development opportunities for students and fellows. We invite you to explore our website and contact us about scientific discussions, collaborations, or career opportunities.