Interrogating mechanisms of
genome instability in cancer evolution
Laboratory of Genome Integrity
Children's Research Institute
UT Southwestern Medical Center
The Ly Laboratory aims to understand how cells maintain genome stability and how dysregulation of these processes impact human health and disease, particularly in the context of cancer development. We study how defects in mitotic cell division, chromosome segregation, and DNA repair pathways shape the chaotic landscape of cancer genomes. Our group is currently focused on exploring how mitotic errors drive large-scale genomic rearrangements, which can span a spectrum of complexity that ranges from simple chromosomal translocations to catastrophic forms of chromothripsis.
We strive to create a supportive laboratory environment aimed at offering exceptional training and career development opportunities for fellows and students. We invite you to explore our website and get in touch with us for discussions, collaborations, and/or career opportunities.