Interrogating mechanisms of catastrophic
genome rearrangements in cancer
Laboratory of Genome Integrity
UT Southwestern Medical Center
Department of Pathology
Using cellular approaches to study cell cycle dynamics, control of genome stability, and cancer genetics
The Ly Lab is broadly interested in the cellular mechanisms of genomic instability and their biological consequences in human health and disease, particularly in the context of cancer development. We study how defects in mitotic cell division, chromosome segregation, centromere regulation, and DNA repair pathways shape the chaotic landscape of cancer genomes. Our group is currently focused on exploring how mitotic errors trigger structural genomic rearrangements, which can span a spectrum of complexity that ranges from simple chromosomal translocations to catastrophic forms of chromothripsis.
We strive to create a supportive, diverse, and inclusive laboratory environment aimed at offering exceptional training and career development opportunities for fellows and students. We invite you to explore our website and get in touch with us for discussions, collaborations, and/or career opportunities.